以上两个词中文意思相近，有时多少可以互相替换使用，但一般情况下应该使用哪个词都已经预定俗成。
store比shop大，所提供的商品和服务也较shop多。Shop通常较小，专门提供一种商品或服务，如keyshop(钥匙店)。
A store is usually larger than a shop and offers many products and services.A shop is usually small,operated by the owner,and provides mainly one product or service.